Endocrine Abstracts

Objectives: Best practice tariff guidelines recommend that paediatric patients with diabetes should have a minimum of four MDT clinic appointments, and an additional eight contacts with the diabetes service per year. This audit compares performance in a DGH against these recommendations. It seeks to determine whether there is a correlation between amount of contact with the service and average HbA1c level.Methods: Analysis of a database recording contact...

Background: Severe hyponatraemia and other electrolyte disturbances secondary to indapamide are documented in the literature. We report two cases that presented with neurological sequelae of profound hyponatraemia without seizures secondary to indapamide.Cases: An 86-year-old female presented with a history of confusion, vomiting and frontal headache associated with lethargy and anorexia. She had been started on indapamide 1 month earlier. She was on no ...

Background: Parathyroid cancer (PC) is a rare tumor associated with poor prognosis particularly when disseminated. Currently, the only effective treatment is a surgical intervention.Case: Starting from the age of 19 a woman had been suffering from bone pains and change in gait. A low-energy right humerus fracture with displacement occurred when she was 23. At the same time, primary hyperparathyroidism (PHPT) was diagnosed for the first time (PTH 569 pg/m...

We present two cases of rare connective tissue disease precipitated by antithyroid medication. The first case is a 37-year-old woman from the Philippines who presented with thyrotoxicosis. She was commenced on Carbimazole, which was subsequently switched to propylthiouracil, as she wanted to become pregnant without delay. Within 2 months she had developed Raynaud’s phenomenon and a facial rash. Autoantibody testing showed a positive ANA of speckled pattern, negative doubl...

A 20-year-old female first presented in 2013 with a six-month history of feeling faint, palpitations, weight loss and oligo-amenorrhoea. She was found to have autoimmune thyrotoxicosis with a fT3 15.2, fT4 43.3, TSH <0.05 and TPO antibodies strongly positive. She was subsequently commenced on Carbimazole 20 mg once a day and was biochemically euthyroid within 6 months. Interestingly, however, she continued to lose weight and remained oligo-amenorrhoeic. ...

A 20-year-old female first presented in 2013 with a six-month history of feeling faint, palpitations, weight loss and oligo-amenorrhoea. She was found to have autoimmune thyrotoxicosis with a fT3 15.2, fT4 43.3, TSH <0.05 and TPO antibodies strongly positive. She was subsequently commenced on Carbimazole 20 mg once a day and was biochemically euthyroid within 6 months. Interestingly, however, she continued to lose weight and remained oligo-amenorrhoeic. ...

Case history: A 20-year-old female first presented to our endocrine clinic in 2013 with a 6-month history of feeling faint, palpitations, weight loss and oligo-amenorrhoea. She was found to have autoimmune thyrotoxicosis with a fT3 of 15.2, fT4 43.3 and TSH <0.05. Her TPO antibodies were strongly positive. She was subsequently commenced on Carbimazole 20 mg once a day and was biochemically euthyroid within 6 months. Interestingly, however, she continued to lose weight and ...

Case history: A 28 year-old male of British origin was referred with a one-year history of a left-sided chest mass and an abnormal chest X-ray. He was otherwise fit and well, had a past medical history of vitiligo and had no relevant family history. His physical examination revealed some hypopigmented spots on his skin, several tattoos across his back and a firm mass on his left upper chest, which was mildly tender on palpation. He had no other palpable masses.<p class="ab...

Background: Increased endogenous post-prandial GLP-1 release is a key mediator of improved glycaemic control following Roux-en-Y gastric bypass (RYGB) surgery. GLP-1 receptor agonists (GLP-1 RA) augment glucose-stimulated-insulin-release and suppress glucagon release, and do not usually cause hypoglycaemia. The use of GLP-1 RA have been shown to be safe for patients requiring additional glycaemic control following RYGB. We present a case of severe recurrent fasting nocturnal h...

Background: Bruns Garlands syndrome is a rare disorder in people living with diabetes, manifesting as unilateral or bilateral muscle pain, weakness and atrophy in the proximal region of the lower limbs. Herein, we present the case of a patient with Bruns-Garland syndrome caused by sodium/glucose co-transporter 2 inhibitors (SGLT2i).Case description: A 55-year-old male with background of type 2 diabetes for 5 years, and currently on oral therapy, presente...